I want to see it happen. They could make the Disney universe one of the multi-verses. It could work as long as you don't make too many crossovers and are careful about continuity. Marvel has had cartoony characters along with realistic ones already. Look at Howard the Duck, who has had an encounter with the Avengers.
EPIC! Sheesh, this needs to happen! I really like this, she would totally say that. I like the detail in their outfits (And her hair of course). Spider-Man is not the easiest to draw, costume-wise, so excellent work on that!